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TB-500 (Thymosin Beta-4) is another regenerative peptide that promotes healing, but it works through different mechanisms, primarily by upregulating actin, a protein critical for cell structure and movement

Evidence-based Management of Vitiligo: Summary of a Cochrane Systematic Review

doi: 10.1038/s41586-024-07182-w 148 TaharaTYamamotoESuzukiHMaruyamaRChungWGarrigaJet al

If severe B12 deficiency with neurological involvement is suspected, treatment should be initiated promptly without waiting for test results, and specialist advice may be needed

Only then can you switch to every-other-day shots or test different doses or frequencies